PACMA 31, CAS 1401089-31-3

Product Description: PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues[1]. PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Applications: Cancer-programmed cell death

Formula: C21H22N2O6S

References: [1]Xu S, et al. Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 2012;109(40):16348-16353.

CAS Number: 1401089-31-3

Molecular Weight: 430.47

Compound Purity: 99.75

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: PDI

• Artikelnummer: MEXHY-100433-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-100433-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK