Palazestrant, CAS 2092925-89-6

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: (1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1-[4-[(1-propyl-3-azetidinyl)oxy]phenyl]-1H-pyrido[3,4-b]indole

Purity: ≥98%

Formula Markup: C28H36FN3O

Formula Weight: 449.603463

CAS Number: 2092925-89-6

Notes: An ERα antagonist (IC50 = 6.4 nM); induces degradation of ERα in MCF-7 cells (EC50 = 0.52 nM); decreases the proliferation of MCF-7 and CAMA-1 breast cancer cells (IC50s = 1.8 and 1.7 nM, respectively); inhibits estradiol-induced cell cycle progression in the same cells at 100 nM; reduces tumor growth and increases survival alone and in combination with ribociclib in an estradiol-stimulated PDX mouse model of breast cancer at 10 mg/kg per day

• Artikelnummer: CAY41843-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 41843-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK