Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (2E)-N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl-d4]-2-propenamide, monohydrochloride
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C21H19D4N3O2 / HCl
Formula Weight: 389.91122
Notes: Panobinostat-d4 (hydrochloride) is intended for use as an internal standard for the quantification of panobinostat (Item No. 13280) by GC- or LC-MS. Panobinostat is a pan-inhibitor of histone deacetylases (HDACs; Kis = 0.6-31 nM for HDAC1-11).{19767} It inhibits growth in a panel of 37 human or mouse lung cancer cell lines, including small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), and mesothelioma cancer cells (IC50s = 4-175, 5-310, and 5-470 nM, respectively), but not NCI H661 mouse NSCLC cells (IC50 = >800 nM).{59793} Panobinostat (20 mg/kg, i.p.) induces tumor regression in BK-T and RG-1 SCLC mouse xenograft models.
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