Pantoprazole-d6, CAS 922727-65-9

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 6-(difluoromethoxy)-2-[[[3,4-di(methoxy-d3)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C16H9D6F2N3O4S

Formula Weight: 389.407286

CAS Number: 922727-65-9

Notes: Pantoprazole-d6 is intended for use as an internal standard for the quantification of pantoprazole (Item No. 21345) by GC- or LC-MS. Pantoprazole is a proton pump inhibitor that inhibits H+/K+-ATPase activity in porcine gastric membrane vesicles with an IC50 value of 6.8 µM.{33533} It reduces basal gastric acid secretion in pylorus-ligated rats (ED50 = 1.3 mg/kg) and inhibits mepirizole-induced increases in gastric acid secretion in an anesthetized rat model of gastric fistula (ED50 = 0.8 mg/kg).{48468} Pantoprazole inhibits formation of mepirizole-induced duodenal lesions in rats (ED50 = 0.5 mg/kg). Formulations containing pantoprazole have been used in the treatment of gastroesophageal reflux disease (GERD) and hypersecretory conditions, including Zollinger-Ellison Syndrome.

• Artikelnummer: CAY28483
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28483-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung