Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N,5-diethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide
Purity: ≥98%
Formula Markup: C21H22N2O3
Formula Weight: 350.4
CAS Number: 248282-01-1
Notes: Paquinimod is an immunomodulator.{52191,52192,52193,52194} In vivo, paquinimod reduces splenic counts of Ly6ChiCD115+ inflammatory monocytes and CD11b+CD11c+ dendritic cells in a mouse model of experimental autoimmune encephalomyelitis (EAE).{52191} Paquinimod (25 mg/kg per day) reduces hepatic fibrosis and accumulation of inflammatory monocytes and neutrophils in the N-IF mouse model of liver fibrosis.{52192} It delays disease onset and decreases insulitis in non-obese diabetic (NOD) mice.{52193} Paquinimod (5 and 25 mg/kg) reduces skin thickness, the number of myofibroblasts, and autoantibody production in the tight skin 1 mouse model of systemic sclerosis.{52194}
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