Paxilline, CAS 57186-25-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 5,6,6a,7,12,12bS,12cR,13,14,14aS-decahydro-4bS-hydroxy-2R-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-1-benzopyrano[5’,6’:6,7]indeno[1,2-b]indole-3(4bH)-one

Purity: ≥98%

Formula Markup: C27H33NO4

Formula Weight: 435.6

CAS Number: 57186-25-1

Notes: Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa) channels, as shown in patch clamp (Ki = 1.9 nM) and whole smooth muscle cell studies (Ki = 35.7 nM).{20615,20614} It also enhances the binding of charybdotoxin (Item No. 24115), a peptidyl neurotoxin, to BKCa channels.{20613} Paxilline is currently used to evaluate the role of BKCa channels in various cell processes and responses.{20612,20616}

• Artikelnummer: CAY11345-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11345-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK