Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-(3-pentylphenyl)acetate, monosodium salt
Purity: ≥98%
Formula Markup: C13H18O2 / Na
Formula Weight: 229.274769
Notes: A FFAR/GPR40 agonist and GPR84 antagonist; induces β-arrestin-2 recruitment in a reporter assay using HEK293 cells expressing human FFAR1/GPR40 (EC50 = 275 µM); inhibits decanoic acid- or embelin-induced activation of GPR84 in reporter assays using HEK293 cells expressing the human receptor (IC50s = 398 and 209 µM, respectively); decreases renal histological lesion scores in a mouse model of doxorubicin-induced nephrotoxicity at 200 mg/kg; reduces tissue fibrosis in several additional in vivo rodent models, including carbon tetrachloride-induced hepatotoxicity and bleomycin-induced pulmonary fibrosis; decreases albuminuria, prevents decreases in GFR and podocyte numbers, and reduces blood glucose levels in a model of accelerated type 2 diabetes using eNos-/- db/db mice at 100 mg/kg
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