Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 6,11-dihydro-[1]benzothiopyrano[4,3-b]indole
Purity: ≥98%
Formula Markup: C15H11NS
Formula Weight: 237.3
CAS Number: 4079-26-9
Notes: PD 146176 is a potent and selective inhibitor of reticulocyte 15-lipoxygenase-1.{16748} It limits hypercholesterolemia-induced atherosclerosis in New Zealand White rabbits and reduces oxidant stress-induced apoptosis in endothelial cells.{16748,16747,16745} PD 146176 inhibits amyloid β protein aggregate formation without changing total levels of amyloid β precursor protein (APP) in cells stably expressing APP.{16746} In addition, it lacks significant non-specific antioxidant properties.{16747}