PD 153035 (hydrochloride), CAS 183322-45-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(3-bromophenyl)-6,7-dimethoxy-4-quinazolinamine, monohydrochloride

Purity: ≥98%

Formula Markup: C16H14BrN3O2 / HCl

Formula Weight: 396.7

CAS Number: 183322-45-4

Notes: Overactivity of the epidermal growth factor receptor-associated tyrosine kinase (EGFR) has been associated with cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread.{18353} PD 153035 is a highly potent, reversible inhibitor of the EGFR (Ki = 5.2 pM; IC50 = 29 pM).{23693} It has been shown to rapidly suppress autophosphorylation of EGFR in fibroblasts and human epidermoid carcinoma cells, as well as to selectively block EGF-mediated cellular processes, including mitogenesis and early gene expression.{23692,23691}

• Artikelnummer: CAY14879-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 14879-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK