Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
Purity: ≥98%
Formula Markup: C21H26ClN3OS
Formula Weight: 404.0
CAS Number: 58-39-9
Notes: Perphenazine is a typical antipsychotic.{24253} It binds to dopamine D2, α1A-, α2A-, α2B-, and α2C-adrenergic, M3 muscarinic, and histamine H1 receptors (Kis = 1.4, 10, 1,848, 104.9, 85.2, 810.5 and 8 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 421, 5.6, 132, 17, and 23 nM, respectively). Perphenazine (1, 5, and 10 mg/kg) enhances morphine-induced analgesia in the tail-flick and hot plate tests in rats.{57432} It reduces cannibalism in female mice when administered at doses of 2 and 4 mg/kg.{57431} Formulations containing perphenazine have been used in the treatment of schizophrenia and psychosis.
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