PF-04620110, CAS 1109276-89-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: trans-4-[4-(4-amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]-cyclohexaneacetic acid

Purity: ≥98%

Formula Markup: C21H24N4O4

Formula Weight: 396.4

CAS Number: 1109276-89-2

Notes: Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final committed step in the biosynthesis of triglycerides and has potential roles in obesity, diabetes, and atherosclerosis.{12021,15816,10960} PF-04620110 is a potent inhibitor of DGAT-1 (IC50 = 19 nM) that is without effect on DGAT-2.{26854} It has high oral bioavailability (100%) in rats, with a moderate half-life of 6.8 hours.{26854} PF-04620110 significantly blocks an increase in plasma triglyceride levels following a corn oil bolus in rats.{26854}

• Artikelnummer: CAY16425-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16425-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK