PF-06826647, CAS 2127109-84-4

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: trans-3-cyano-1-[4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl]-cyclobutaneacetonitrile

Purity: ≥98%

Formula Markup: C20H17N9

Formula Weight: 383.4

CAS Number: 2127109-84-4

Notes: PF-06826647 is an inhibitor of tyrosine kinase 2 (TYK2; IC50 = 15 nM).{67650} It is selective for TYK2 over JAK1, JAK2, and JAK3 (IC50s = 383, 74, and >10,000 nM, respectively). PF-06826647 inhibits IL-12-induced phosphorylation of STAT4 in isolated human whole blood (IC50 = 14 nM). In vivo, PF-06826647 (3-30 mg/kg, p.o.) reduces ear edema in a mouse model of skin inflammation induced by the toll-like receptor 7 (TLR7) agonist imiquimod (Item No. 14956).

• Artikelnummer: CAY37577-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37577-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK