PF-8380, CAS 1144035-53-9

Product Description: PF-8380 is a potent autotaxin inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.

Applications: Cancer-Kinase/protease

Formula: C22H21Cl2N3O5

References: [1]Gierse J, et al. A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. J Pharmacol Exp Ther. 2010 Jul;334(1):310-7./[2]Bhave SR, et al. Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines. Front Oncol. 2013 Sep 17;3:236./[3]Cao P, et al. Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis. J Clin Invest. 2017 Apr 3;127(4):1517-1530.

CAS Number: 1144035-53-9

Molecular Weight: 478.332

Compound Purity: 99.04

Research Area: Cancer; Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Phosphodiesterase (PDE)

• Artikelnummer: MEXHY-13344-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-13344-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK