PF 9601N, CAS 133845-63-3

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 5-(phenylmethoxy)-N-2-propyn-1-yl-1H-indole-2-methanamine

Purity: ≥98%

Formula Markup: C19H18N2O

Formula Weight: 290.3591

CAS Number: 133845-63-3

Notes: PF 9601N is an inhibitor of monoamine oxidase B (MAO-B).{64032} It selectively inhibits MAO-B in mouse brain homogenates ex vivo (ID50 = 381 nmol/kg) and prevents MPTP-induced reductions in dopamine levels in the striatum of 8- to 9-week-old mice when administered at doses ranging from 29.5 to 8.47 µmol/kg. PF 9601N (0.027 µmol/kg) prevents MPTP-induced lesions in 9- to 10-month-old mice. It also increases the duration of contralateral rotational behavior induced by L-DOPA (Item No. 13248) in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330) when administered at doses of 40 and 60 mg/kg.{64033}

• Artikelnummer: CAY34258-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34258-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK