Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 5-(3,5-dimethyl-4-isoxazolyl)-1-[2-(4-morpholinyl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-benzimidazole
Purity: ≥98%
Formula Markup: C29H36N4O3
Formula Weight: 488.6
CAS Number: 1962928-21-7
Notes: CREB-binding protein (CBP) and E1A-associated protein p300 are transcriptional co-activators that modulate DNA replication, DNA repair, cell growth, transformation, and development.{22609,22611} Both CBP and p300 contain bromodomains, which mediate their binding to acetylated lysine residues on histones and other proteins.{21581} PF-CBP1 is an inhibitor of the CBP and p300 bromodomains (IC50s = 125 and 363 nM, respectively).{30310} It displays greater than 100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins.{30310} PF-CBP1 reduces the expression of inflammatory cytokines by LPS-stimulated primary macrophages.{30310} It also suppresses the expression of RGS4 (regulator of G protein signaling 4) in primary cortical neurons.{30310}
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