Phenamil (methanesulfonate), CAS 1161-94-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]-2-pyrazinecarboxamide, monomethanesulfonate

Purity: ≥98%

Formula Markup: C12H12ClN7O / CH3SO3H

Formula Weight: 401.8

CAS Number: 1161-94-0

Notes: Phenamil is an inhibitor of transient receptor potential polycystin-L (TRPP3; IC50 = 140 nM) and a derivative of amiloride (Item No. 14409).{24798} It also inhibits the epithelial sodium channel (ENaC; IC50 = 400 nM).{55255} Phenamil decreases basal short-circuit currents in human and ovine bronchial epithelial cells with IC50 values of 75 and 116 nM, respectively.{24797} It inhibits potassium chloride-induced contractions in isolated rat endothelium-denuded aortic rings (EC50 = 6.76 µM) and increases contractile force in isolated rat right ventricular papillary muscles (EC50 = 16.98 µM).{55253} Phenamil (15 and 30 mg/kg per day) reduces pulmonary artery medial wall thickness and decreases right ventricular peak pressure in a rat model of chronic hypoxia-induced pulmonary hypertension.{55254}

• Artikelnummer: CAY14308-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 14308-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK