Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (2-phenylethyl-d5)-hydrazine, monosulfate
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C8H7D5N2 / H2SO4
Formula Weight: 239.30414
CAS Number: 1219798-40-9
Notes: Phenelzine-d5 (sulfate) is intended for use as an internal standard for the quantification of phenelzine (Item No. 23956) by GC- or LC-MS. Phenelzine is an inhibitor of monoamine oxidase (MAO; IC50 = 0.9 μM using rat brain mitochondrial preparations).{38498} It potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice with LD50 values of 85 and 500 mg/kg in the presence and absence of phenelzine, respectively. Phenelzine (20 mg/kg) increases GABA, dopamine, serotonin (5-HT; Item No. 14332), and norepinephrine levels in the hippocampus and cortex of socially isolated rats and rats treated with the NMDA receptor antagonist (+)-MK-801 (Item No. 10009019).{38499} It also increases 5-HT levels in the ventral horn of the spinal cord, improves gross motor ability in a rotarod test, and increases locomotor activity in an open field test in mice with experimental autoimmune encephalomyelitis when administered at a dose of 30 mg/kg.{38500}
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