Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[2-(phenyl-2,3,4,5,6-d5)ethyl]-imidodicarbonimidic diamide, monohydrochloride
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C10H10D5N5 / HCl
Formula Weight: 246.75074
Notes: Phenformin-d5 is intended for use as an internal standard for the quantification of phenformin by GC- or LC-MS. Phenformin is an antihyperglycemic biguanide.{64389} It reduces blood glucose levels in a mouse model of diabetes induced by alloxan (Item No. 9002196) when administered at a dose of 100 mg/kg. Phenformin (250 mg/kg) induces lactic acidosis in diabetic dogs.{64390} It also inhibits tumor growth of MCF-7 and MDA-MB-231 breast cancer mouse xenograft models when administered at a dose of 300 mg/kg.{24105} Formulations containing phenformin were previously used in the treatment of diabetes mellitus.
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