Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4-[(1S,3aR,4R,6aR)-4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxy-phenol
Purity: ≥95%
Formula Markup: C21H24O6
Formula Weight: 372.41166
CAS Number: 487-39-8
Notes: Phillygenin is a lignan that has been found in F. fructus and has diverse biological activities.{56162,56163,56165} It scavenges peroxide and DPPH (Item No. 14805) radicals in cell-free assays (IC50s = 10.5 and 19.1 µM, respectively).{56162} Phillygenin (25-200 µg/ml) inhibits LPS-induced production of IL-1β, IL-6, TNF-α, and the fibrosis markers collagen I and α-SMA in LX-2 hepatic stellate cells.{56163} It also reduces serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase (SOD), and malondialdehyde (MDA) and prevents hepatic necrosis in a mouse model of carbon tetrachloride-induced liver injury.{56165}
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