Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (2R,3S,4S,5R,6R)-2-(((2R,3S,4S,5S,6S)-2-(2-(6-amino-2-(3-amino-1-((2,3-diamino-3-oxopropyl)amino)-3-oxopropyl)-5-methylpyrimidine-4-carboxamido)-3-((5-((1-((2-(4-((4-guanidinobutyl)carbamoyl)-4',5'-dihydro-[2,4'-bithiazol]-2'-yl)ethyl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-3-hydroxy-4-methyl-5-oxopentan-2-yl)amino)-1-(1H-imidazol-4-yl)-3-oxopropoxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl carbamate, copper(II) salt, monohydrochloride
Purity: ≥95% (mixture of phleomycins)
Formula Markup: C55H84N20O21S2Cu / HCl
Formula Weight: 1525.5
CAS Number: 11006-33-0
Notes: Phleomycin is a glycopeptide antibiotic that has been found in S. verticillus and has diverse biological activities.{25379,25378,25377,25381,25380} It induces chromosomal breaks in S. cerevisiae when used at concentrations ranging from 1 to 2 µM.{25379} Phleomycin (5 or 10 µg/ml) reduces proliferation, DNA synthesis, and the percentage of cells entering mitosis in HeLa cervical cancer cells.{25378} In vivo, phleomycin (1 mg/kg per day), in combination with the purine analog LS34, increases survival time in an Ehrlich mouse ascites tumor model.{25377} It has been used as an antibiotic selection agent for successfully transformed cells in genetic engineering experiments.{25381},{25380}
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