PI-103 (hydrochloride), CAS 371935-79-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-phenol, monohydrochloride

Purity: ≥98%

Formula Markup: C19H16N4O3 / HCl

Formula Weight: 384.8

CAS Number: 371935-79-4

Notes: PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members with selectivity toward DNA-PK, PI3K (p110α), and mTORC1. The IC50 values are 2, 8, 20, 26, 48, 83, 88, and 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γ, respectively.{14312} PI-103 exhibits antiproliferative activity against a panel of glioma cell lines in vitro at a concentration of 0.5 µM. It also inhibits growth of established human glioma tumor xenografts in vivo with no observable toxicity.{14311}

• Artikelnummer: CAY21187-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21187-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK