Target Synonym: PIAS4;PIAS-gamma;PIASY;Piasg;ZMIZ6
Storage: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Background: Functions as an E3-type small ubiquitin-like modifier (SUMO ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunogen: Recombinant fusion protein of human PIAS4
Dilution: WB 1:500-1:2000
Calculated MW: 56kDa
Observed MW: 57kDa
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