PIK-III, CAS 1383716-40-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4'-(cyclopropylmethyl)-N2-4-pyridinyl-[4,5'-bipyrimidine]-2,2'-diamine

Purity: ≥98%

Formula Markup: C17H17N7

Formula Weight: 319.4

CAS Number: 1383716-40-2

Notes: PIK-III is an inhibitor of the type 3 phosphatidylinositol 3-kinase (PI3K) vacuolar protein sorting 34 (Vps34) that binds a unique hydrophobic pocket (IC50 = 18 nM).{27535} It is selective for Vps34 over related PI3K isoforms, PI4Kβ, and mTOR. PIK-III acutely inhibits autophagy and de novo lipidation of LC3, leading to stabilization of autophagy substrates.{27535}

• Artikelnummer: CAY17002-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 17002-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK