Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (2S,5R,6R)-6-((R)-2-(4-(ethyl-d5)-2,3-dioxopiperazine-1-carboxamido)-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C23H22D5N5O7S
Formula Weight: 522.58628
Notes: Piperacillin-d5 is intended for use as an internal standard for the quantification of piperacillin (Item No. 20766) by GC- or LC-MS. Piperacillin is a broad-spectrum β-lactam antibiotic of the penicillin class.{27901,29941} It is active against Gram-negative and Gram-positive bacteria, including Enterococcus species, E. coli, and P. mirabilis (MIC50s = 0.5-2 µg/ml) as well as gentamicin-susceptible and -resistant strains of P. aeruginosa (MIC50s = 8 and 125 µg/ml, respectively).{29941} In a mouse model of systemic infection, piperacillin is active against P. aeruginosa 46220 when used alone or in combination with tazobactam (Item No. 25679; ED50s = 1.58 and 1.34 mg/animal, respectively).{37701} In the same model, it is less active against P. aeruginosa 46220 DR-2, which contains constitutively active β-lactamase, when used alone than when used in combination with tazobactam (ED50s = >20 and 4.39 mg/animal, respectively). Formulations containing piperacillin in combination with tazobactam have been used in the treatment of moderate-to-severe bacterial infections.
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