Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-2,4-pentadien-1-one
Purity: ≥98%
Formula Markup: C17H19NO3
Formula Weight: 285.3
CAS Number: 94-62-2
Notes: Piperine is a natural alkaloid that can be isolated from black pepper. It activates transient receptor potential vanilloid type 1 receptor (TRPV1; EC50 = 38 µM) and modulates GABAA receptors (EC50s = 43-60 µM).{27597,27596} At similar levels, piperine inhibits both monoamine oxidases (MAOs), with IC50 values of 21 and 7 µM for MAO-A and MAO-B, respectively.{27595} Like other natural compounds containing methylenedioxyphenyl substituents, piperine affects cytochrome P450 (CYP) isoforms, inhibiting CYP3A species (Ki ~ 5 µM) and increasing expression of CYP1A and CYP2B in liver.{25115} It also has a biphasic effect on P-glycoprotein activity.{25373}
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