Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid, hemicalcium salt
Purity: ≥98%
Formula Markup: C25H23FNO4 /1/2Ca
Formula Weight: 440.5
CAS Number: 147526-32-7
Notes: Pitavastatin is an HMG-CoA reductase inhibitor (Ki = 1.7 nM for the rat liver microsomal enzyme).{25250} It inhibits sterol biosynthesis in rat liver and ileum (ED50s = 0.13 and 0.2 mg/kg, respectively) and reduces plasma levels of triglycerides and total cholesterol in dogs. Pitavastatin (0.3 mg/kg) increases survival in Dahl salt-sensitive rats fed a high-salt diet, a model of hypertensive heart failure.{25247} Formulations containing pitavastatin have been used in the treatment of hyperlipidemia, mixed dyslipidemia, and heterozygous familial hypercholesterolemia.
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