Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-phenylhydrazide-4-pyridinecarboxylic acid
Purity: ≥95%
Formula Markup: C12H11N3O
Formula Weight: 213.2
CAS Number: 91396-88-2
Notes: PluriSln 1 is an N-acyl phenylhydrazine derivative that inhibits stearoyl-CoA desaturase, a key enzyme for lipid metabolism that is expressed in human pluripotent stem cells (hPSCs).{26485} PluriSln 1 can selectively induce ER stress, attenuate protein synthesis, and induce apoptosis in hPSCs (EC50 = 2 µM) while sparing progenitor and differentiated cells.{26485} Because PluriSln 1 can selectively eliminate undifferentiated hPSCs, it was developed as a strategy to prevent tumorigenic risk from residual undifferentiated cells used during stem cell therapy. In immunocompromised mice, PluriSln 1 has been shown to effectively prevent teratoma formation from undifferentiated hPSCs.{26485}
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