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Background: FAK (Focal Adhesion Kinase; PTK2) is a protein kinase involving cell adhesion and migration. FAK plays an important role in many cancers including pancreatic tumors. In addition, recent studies showed FAK inhibitor enables an anti-tumor immune response, resulting in tumor destruction in a mouse model.
CAS Number: 1061353-68-1
Description: PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis.1
Format: Aqueous solution
Purity: ≥90%
Storage Stability: Powder, store up to 3 years at -20°C or up to 2 years at 4°C. In solvent, store up to 2 years at -80°C or up to 1 year at -20°C
Target: FAK
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Tanjoni I, et al., 2010 Cancer Biol Ther. 9(10): 764-77.
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