Poloppin, CAS 683808-78-8

Product Description: Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26.9 μM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29.5 μM). Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis. Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors[1].

Applications: COVID-19-anti-virus

Formula: C20H15BrF3NO2

References: [1]Ana J Narvaez, et al. Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS. Cell Chem Biol. 2017 Aug 17;24(8):1017-1028.e7.

CAS Number: 683808-78-8

Molecular Weight: 438.24

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Autophagy;Mitosis;Polo-like Kinase (PLK)

• Artikelnummer: MEXHY-124761-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-124761-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK