Product Description: Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.
Applications: Cancer-Kinase/protease
Formula: C10H13NO2
References: [1]Liu M, et al. Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors. Bioorg Med Chem Lett. 2015 Feb 1;25(3):431-4./[2]Yin Z, et al. Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic. ACS Chem Biol. 2013 Feb 15;8(2):303-8.
CAS Number: 17302-61-3
Molecular Weight: 179.22
Compound Purity: 95.0
Research Area: Cancer
Solubility: DMSO : ≥ 100 mg/mL/H2O : < 0.1 mg/mL (ultrasonic)
Target: Polo-like Kinase (PLK)