Poloxin, CAS 321688-88-4

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 1-[O-(2-methylbenzoyl)oxime]2-methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione

Purity: ≥98%

Formula Markup: C18H19NO3

Formula Weight: 297.4

CAS Number: 321688-88-4

Notes: Poloxin is an inhibitor of the polo-like kinase 1 (Plk1) polo-box domain (PBD; apparent IC50 = 4.8 µM).{69049} It is selective for the Plk1 PBD over Plk2 and Plk3 PBDs (IC50s = 18.7 and 53.9 µM, respectively). Poloxin (5, 10, and 25 µM) induces cell cycle arrest at the G2/M phase, apoptosis, and mislocalization of Plk1 in HeLa cells. It reduces cell proliferation in a panel of 10 cancer cell lines (EC50s = 15-35 µM).{69050} In vivo, poloxin (40 mg/kg) reduces tumor growth and induces intratumor apoptosis in an MDA-MB-231 breast cancer mouse xenograft model.

• Artikelnummer: CAY36018-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36018-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe