Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one
Purity: ≥98% deuterated forms (d1-d5)
Formula Markup: C37H37D5F2N8O4
Formula Weight: 705.8
CAS Number: 2649530-57-2
Notes: Posaconazole-d5 is intended for use as an internal standard for the quantification of posaconazole (Item No. 14737) by GC- or LC-MS. Posaconazole is a broad-spectrum triazole antifungal agent active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes.{20805} Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase enzyme (IC50s = 7-200 nM), which results in a disruption in the synthesis of ergosterol (Item No. 19850), a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins.{24400}
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