Target: PP5
Conjugate: HRP
Product Type: Monoclonal
Clone Number: 12F7
Immunogen: Full length human PP5 protein
Swiss-Prot: P53041
Purification: Protein G Purified
Storage Buffer: 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O
Concentration: 1 mg/ml
Specificity: Detects ~58kDa.
Cellular Localization: Nucleus / Cytoplasm
Scientific Background: Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues, potentially playing a role in the regulation of cell growth and differentiation. PP5 or PPT is predominantly a nuclear protein and interacts with CDC16 and CDC27. It is found in association with several proteins that influence intracellular signlaing-cascades intitiated by hormones (glucocorticoids) or cellular stress (hypoxia, oxidative stress and DNA Damage). It phosphorylates serine residues of skeletal muscle phosphorylase and histone H1. It may also be involved in mitosis and RNA biogenesis regulation (1,2).
References: 1. Butzow R., et al. (1988) J Lab Clin Med. 111(2): 249-256.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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