Product Description: PRIMA-1 (NSC-281668) is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.
Applications: Cancer-programmed cell death
Formula: C9H15NO3
References: [1]Cui B, et al. PRIMA-1, a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A. J Clin Endocrinol Metab. 2014 Jun;99(6):E962-70./[2]Zhang Z, et al. Targeting cancer stem cells with p53 modulators. Oncotarget. 2016 Apr 8./[3]Rao CV, et al. Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice. Neoplasia. 2013 Sep;15(9):1018-27.
CAS Number: 5608-24-2
Molecular Weight: 185.223
Compound Purity: 98.0
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic)/H2O : 100 mg/mL (ultrasonic)
Target: Apoptosis;Autophagy;Ferroptosis;MDM-2/p53
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