Product Description: Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice[1][2].
Applications: Cancer-programmed cell death
Formula: C45H38O18
References: [1]Koteswari LL, et al. A comparative anticancer study on procyanidin C1 against receptor positive and receptor negative breast cancer. Nat Prod Res. 2019 Jan 8:1-8./[2]Xu Q, et al. The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice. Nat Metab. 2021 Dec;3(12):1706-1726.
CAS Number: 37064-30-5
Molecular Weight: 866.77
Compound Purity: 99.54
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : 50 mg/mL (ultrasonic)
Target: Apoptosis
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