Product Description: Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity[1][2].
Applications: Cancer-programmed cell death
Formula: C20H19NO5
References: [1]Kim SR, et, al. Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities. Planta Med. 1999 Apr;65(3):218-21. /[2]Nie C, et, al. Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma. Cancer Cell Int. 2021 Jul 27;21(1):396./[3]Xu LF, et al. Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models. Neuropharmacology. 2006 Jun;50(8):934-40. /[4]Xiao X, et al. Protective effect of protopine on the focal cerebral ischaemic injury in rats. Basic Clin Pharmacol Toxicol. 2007 Aug;101(2):85-9.
CAS Number: 130-86-9
Molecular Weight: 353.37
Compound Purity: 99.64
Research Area: Cancer; Infection; Inflammation/Immunology; Neurological Disease
Solubility: DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Cholinesterase (ChE)
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