Product Description: PRT-060318 (PRT318) is a novel selective inhibitor of the tyrosine kinase Syk with an IC50 of 4 nM.
Applications: Cancer-Kinase/protease
Formula: C18H24N6O
References: [1]Reilly MP, et al. PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model. Blood. 2011 Feb 17;117(7):2241-6./[2]Hoellenriegel J, et al. Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration. Leukemia. 2012 Jul;26(7):1576-83.
CAS Number: 1194961-19-7
Molecular Weight: 340.42
Compound Purity: 99.04
Research Area: Cancer
Solubility: H2O : 25 mg/mL (ultrasonic)
Target: Syk