Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (3ß,25R)-26-(ß-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-a-L-mannopyranosyl-(1?2)-O-[6-deoxy-ß-D-glucopyranoside
Purity: ≥98%
Formula Markup: C51H82O21
Formula Weight: 1031.18418
CAS Number: 102115-79-7
Notes: Pseudoprotodioscin is a steroidal saponin that has been found in D. panthaica and has diverse biological activities.{62005,62006,62007} It is cytotoxic to A375, L929, and HeLa cancer cells (IC50s = 5.73, 5.09, and 3.32 µM, respectively).{62005} Pseudoprotodioscin (2 µM) increases nuclear accumulation of estrogen receptor α (ERα) in 3T3-L1 preadipocytes cultured in differentiation medium.{62006} It inhibits LPS-induced increases in NF-κB activity in reporter assays using isolated mouse peritoneal macrophages and human umbilical vein endothelial cells (HUVECs) when used at a concentration of 2.5 µM.{62007} Pseudoprotodioscin (1, 2.5, and 5 mg/kg) reduces atherosclerotic plaque area and inhibits increases in serum total cholesterol and triglyceride levels in ovariectomized ApoE-/- mice fed a high-cholesterol diet.
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