Product Description: PSN 375963 is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 shows similar potency to the endogenous agonist oleoylethanolamide (OEA)[1][2].
Applications: Metabolism-sugar/lipid metabolism
Formula: C17H23N3O
References: [1]Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3(3):167-175./[2]Ning Y, et al. Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br J Pharmacol. 2008;155(7):1056-1065.
CAS Number: 388575-52-8
Molecular Weight: 285.38
Compound Purity: 99.96
Research Area: Endocrinology
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: GPR119
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