PT2385, CAS 1672665-49-4

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 3-[[(1S)-2,2-difluoro-2,3-dihydro-1-hydroxy-7-(methylsulfonyl)-1H-inden-4-yl]oxy]-5-fluoro-benzonitrile

Purity: ≥98%

Formula Markup: C17H12F3NO4S

Formula Weight: 383.3

CAS Number: 1672665-49-4

Notes: PT2385 is an inhibitor of hypoxia-inducible factor-2α (HIF-2α; IC50 = 12 nM).{68806} It inhibits HIF-2α-induced transcription of intratumoral Vegfa mRNA and reduces tumor volume in a 786-O renal cell carcinoma mouse xenograft model when administered at a dose of 10 mg/kg. PT2385 (20 mg/kg) also inhibits the production of soluble FMS-related tyrosine kinase 1 (sFlt1) and prevents the development of hypertension and proteinuria, markers of preeclampsia, in pregnant rat dams.{68807}

• Artikelnummer: CAY21325-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21325-100
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK