Pyrimidinone 8, CAS 65004-42-4

Pyrimidinone 8, CAS 65004-42-4
Artikelnummer
MEXHY-124703-0
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MedChemExpress

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Product Description: Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 μM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 μM[1].

Applications: Neuroscience-Neuromodulation

Formula: C10H12N4O

References: [1]Montalbetti N, et al. Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2. Biochem Pharmacol. 2015 Aug 1;96(3):216-24.

CAS Number: 65004-42-4

Molecular Weight: 204.23

Research Area: Others

Target: Ferroportin
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Artikelnummer MEXHY-124703-0
Hersteller MedChemExpress
Hersteller Artikelnummer HY-124703-0
Verpackungseinheit Get quote
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