Product Description: Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis[1].
Applications: Cancer-programmed cell death
Formula: C23H32Cl3N3O
References: [1]Xiaoyang Wu, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73(1-2):52-64./[2]Anna Eriksson, et al. Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects. Leuk Res. 2017 Dec;63:41-46.
CAS Number: 69-05-6
Molecular Weight: 472.88
Compound Purity: 99.38
Research Area: Cancer; Infection
Solubility: H2O : 13.89 mg/mL (ultrasonic)
Target: Apoptosis;Autophagy;Mitophagy;Parasite
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