Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenyl-d5-propyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C25H25D5N2O5
Formula Weight: 443.6
CAS Number: 1279029-79-6
Notes: Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril (Item No. 21439) by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat.{30687,33593} In vivo, quinapril (3 mg/kg) reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats.{33593} It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril (10-200 mg/kg) prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations containing quinapril have been used in the treatment of hypertension, heart failure, and diabetic nephropathy.
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