Quinidine, CAS 56-54-2

Formulation: A crystalline solid

Formal Name: 6'-methoxy-cinchonan-9S-ol

Purity: ≥95% (may contain up to 15% hydroquinidine)

Formula Markup: C20H24N2O2

Formula Weight: 324,4

Shelf life (days): 1460

CAS Number: 56-54-2

Notes: Quinidine is a stereoisomer of the antimalarial agent quinine (Item No. 23958) and a class Ia antiarrhythmic agent.{37790,37791} Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner.{37790} It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes.{37792} It inhibits KKr, peak INa, and late INa (IC50s = 4.5, 11, and 12 µM, respectively) and can induce torsade de pointes in isolated rabbit hearts when used at a concentration of 1 µM.{37791} Quinidine induces QT prolongation in dogs.{37793} It also binds to M2 muscarinic acetylcholine receptors (Ki = 7.5 µM for human recombinant receptors expressed in HM2-B10 cells).{37794} Formulations containing quinidine have been used in the treatment of atrial fibrillation and ventricular arrhythmias.

• Artikelnummer: CAY20356-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20356-50
• Green Labware: Nein
• Verpackungseinheit: 50 g
• Mengeneinheit: STK