R-268712, CAS 879487-87-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[2-fluoro-5-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]-1H-pyrazole-1-ethanol

Purity: ≥98%

Formula Markup: C20H18FN5O

Formula Weight: 363.388423

CAS Number: 879487-87-3

Notes: R-268712 is an inhibitor of activin receptor-like kinase (ALK5; IC50 = 2.5 nM).{69407} It is selective for ALK5 over p38 MAPK (IC50 = 12 µM). R-268712 (1, 3, and 10 mg/kg) reduces renal fibrosis in a model of unilateral ureteral obstruction using transgenic Col1a1-Luc Tg rats, a reporter model for collagen I expression. It also reduces proteinuria and glomerulosclerosis and improves renal function in heminephrectomized rats in a model of glomerulonephritis using antibodies against Thy-1 membrane glycoprotein when administered at doses of 0.3 and 1 mg/kg.

• Artikelnummer: CAY36810-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36810-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK