Product Description: (R)-Carvedilol-d4 is deuterium labeled (R)-Carvedilol. (R)-Carvedilol ((R)-BM 14190), the R-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (R)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX)[1].
Applications: Neuroscience-Neuromodulation
Formula: C24H22D4N2O4
References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Wu T, et al. Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39(8):1233-1244.
CAS Number: 2747915-92-8
Molecular Weight: 410.50
Research Area: Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: Adrenergic Receptor;Isotope-Labeled Compounds