Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl-3,3,4,5,5-d5)-1H-pyrazol-4-yl]-2-pyridinamine
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C21H17Cl2D5FN5O
Formula Weight: 455.366583
CAS Number: 1395950-84-1
Notes: (R)-Crizotinib-d5 is intended for use as an internal standard for the quantification of (R)-crizotinib (Item No. 12087) by GC- or LC-MS. (R)-Crizotinib is a derivative of aminopyridine that acts as a potent, orally bioavailable, ATP-competitive small-molecule dual inhibitor of c-MET (IC50 = 8 nM) and ALK (IC50 = 20 nM) receptor tyrosine kinases.{22302} (R)-Crizotinib shows antitumor efficacy, including cytoreductive antitumor activity, in multiple tumor models implanted in athymic mice that express activated c-MET or ALK fusion proteins (IC50s = 5-20 nM).{22302,22301}
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