RAD51 (Prognostic and Response to Chemotherapy Marker)(RAD51/2701), CF740 conjugate, 0.1mg/mL

RAD51 (Prognostic and Response to Chemotherapy Marker)(RAD51/2701), CF740 conjugate, 0.1mg/mL
Artikelnummer
BTMBNC742701-100
Verpackungseinheit
100 uL
Hersteller
Biotium

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Description: RAD51 is one of the key factors of DNA repair by homologous recombination and has been shown to have anti-apoptotic activity in tumor cells. RAD51 protein interacts with a variety of tumor suppressor proteins including p53, BRCA1 and BRCA2. Elevated expression of RAD51 enhances radio-resistance of human tumor cells. Overexpression of RAD51 protein in tumor cells renders them resistant against cytotoxic drugs like Cisplatin. RAD51 interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of RAD51. High-level expression of RAD51 has been observed in a variety of human malignancies. RAD51 overexpression correlates with histological grading of the tumor in invasive ductal mammary carcinoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)

Conjugate: CF740

Concentration: 0.1 mg/mL

Storage buffer: PBS, 0.1% rBSA, 0.05% azide

Clone: RAD51/2701

Immunogen: Recombinant fragment of human RAD51 protein (around aa 1-134) (exact sequence is proprietary)

Antibody Reactivity: RAD51

Entrez Gene ID: 5888

Z-Antibody Applications: Flow, intracellular (verified)/WB (verified)

Verified AB Applications: Flow (intracellular) (verified)/WB (verified)
Mehr Informationen
Artikelnummer BTMBNC742701-100
Hersteller Biotium
Hersteller Artikelnummer BNC742701-100
Verpackungseinheit 100 uL
Mengeneinheit STK
Reaktivität Human
Klonalität Monoclonal
Methode Western Blotting, Flow Cytometry
Isotyp IgG2b kappa
Wirt Mouse
Konjugat Conjugated, CF740
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