Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (16ß,17a,20a)-17-hydroxy-yohimban-16-carboxylic acid, methyl ester, monohydrochloride
Purity: ≥98%
Formula Markup: C21H26N2O3 / HCl
Formula Weight: 390.9
CAS Number: 6211-32-1
Notes: Rauwolscine is a natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM).{25653} It is a stereoisomer of yohimbine, which potently antagonizes both α1- and α2-adrenergic receptors.{25653} Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki = 14.3 nM) and as a weak partial agonist at 5-HT1A (IC50 = 1.3 µM).{25654,25657,25652} The α2-adrenergic receptor has diverse physiological functions and antagonists like rauwolscine have numerous applications, including the modulation of mood and behavior.{25656,25655}