Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: a-[(4-chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid
Purity: ≥98%
Formula Markup: C19H15ClN2O4
Formula Weight: 370.8
CAS Number: 90098-04-7
Notes: Rebamipide is a gastroprotective agent and mucin secretagogue.{61256} It increases the levels of prostaglandin E2 (PGE2) and COX-2 in rat gastric mucosa when administered at doses of 15 and 50 mg/kg per day. Rebamipide (30 and 100 mg/kg, i.p.) prevents the formation of gastric ulcers induced by absolute ethanol, sodium hydroxide, or hydrochloric acid in rats, an effect that can be blocked by the non-selective COX inhibitor indomethacin (Item No. 70270).{61257} It also increases the production of mucin 16 in stratified corneal epithelial cells in vitro when used at concentrations of 10 and 100 µM.{61258} Rebamipide (1% w/v) increases the levels of mucin-like substances in rabbit conjunctiva and cornea and, in a rabbit model of dry eye disease, reduces desiccation-induced corneal damage.{61259} Formulations containing rebamipide have been used in the treatment of peptic ulcer disease and dry eye disease.
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